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Several major modern human rabies vaccines include duck embryo vaccine, commercialized in 1957; human diploid cell vaccine, introduced in 1978; purified chicken embryo cell vaccine, developed in 1984; and a purified Vero cell rabies vaccine (PVRV), developed in the late 1980s.
RabAvert also has proven effective in boosting titers when administered as a booster dose to individuals (n = 67) who previously were immunized with RabAvert or a human diploid cell vaccine.
Six were bat handlers who had received postexposure treatment with five doses of rabies human diploid cell vaccine (HDCV) during a 1996 campaign that followed the diagnosis of the first human case of ABL (2,7).