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4 nM, respectively), moderate affinity for dopamine D4, serotonin 5-HT2C and 5-HT7, alpha1-adrenergic and histamine H1 receptors (Ki values of 44, 15, 39, 57, and 61 nM, respectively), and moderate affinity for the serotonin reuptake site (Ki=98 nM).
The preclinical data found that lurasidone binds weakly to histamine H1 receptors, which have been implicated in weight gain and sedation, to the 5HT2C receptor, which has also been implicated in weight gain, and to muscarinic receptors, which might be involved in some of the cognitive effects associated with antipsychotics, said Dr.
Bepotastine besilate is a non-sedating, highly selective antagonist of the histamine H1 receptor.
5% is a histamine H1 receptor antagonist indicated for the treatment of itching associated with signs and symptoms of allergic conjunctivitis.