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LIPOFEN is indicated as adjunctive therapy to diet to reduce elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, and to increase high-density lipoprotein cholesterol in adult patients with primary hypercholesterolemia or mixed dyslipidemia.
Despite the limitations and the relatively small size of this study, these authors propose that by employing lipid ratios and high-density lipoprotein cholesterol (HDL-C) levels for screening, early identification of South Africans living with HIV and at risk for CVD may be achieved.
Blood samples obtained during physical examinations were analyzed for glucose, fasting insulin, C-reactive protein, fibrinogen, homocysteine, triglycerides, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1, apolipoprotein B, and 25-hydroxyvitamin D [25(OH)D].
Study leader Dr Zhen-Yu Chen, from the Chinese University of Hong Kong, said: "Total cholesterol, low-density lipoprotein cholesterol (LDL), and the heart-healthy high-density lipoprotein cholesterol (HDL) are still important health issues.
They also had higher levels of "good" high-density lipoprotein cholesterol, and lower levels of "bad" low-density lipoprotein (LDL) cholesterol.
At the same time, the researchers also identified a substantial proportion of normal weight adults who have two or more of the cardiometabolic abnormalities that signal high cardiovascular disease risk, including elevated blood pressure; elevated levels of triglycerides, fasting plasma glucose, and C-reactive protein; and low high-density lipoprotein cholesterol level.
The LDL-C is typically calculated with the Friedwald formula, which requires the measurement of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) (2).
Assuming that your lipid panel reports total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), your best bet is to send very lipemic specimens to an National Heart, Lung and Blood Institute-Centers for Disease Control and Prevention (NHLBI-CDC) standardized laboratory, (1) which uses the classical preparative ultracentrifuge procedure.