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Samples in periodicals archive:
High mobility group box 1 protein as a potential drug target for infection- and injury-elicited inflammation.
High mobility group box 1 protein (HMGB1) maintains the nucleosome structure and regulates gene transcription, can be released by necrotic cell or activated innate immune cells (Lotze and Tracey 2005).
Preclinical results from several of MedImmune's inflammation biology programs were also presented at the AAI meeting, including new information about the role High Mobility Group Box Protein 1 (HMGB1) may play in inflammatory disorders.
PARIS, France, and COLLERETTO GIACOSA, Italy, November 14 /PRNewswire/ -- Nautilus Biotech SA and Creabilis Therapeutics SpA have announced that they have shown increased biological activity and resistance to proteolysis in vitro of the High Mobility Group Box One (HMGB1) Box A protein, an important technical milestone in their collaboration to identify a potential candidate drug for the treatment of RAGE- (Receptor for Advanced Glycation End products) and HMGB1-related pathologies, which include hepatitis B, rheumatoid arthritis, melanoma and sepsis.
7,060,504, "Antagonists of HMG1 for Treating Inflammatory Conditions," involves methods of measuring the concentration of the protein High Mobility Group Box 1 (HMGB1) and comparing that concentration to a representative normal sample.
Nasdaq: CRTX) today announced the achievement of a preclinical, proof-of-concept milestone in its High Mobility Group Box 1 (HMGB1) program with MedImmune, Inc.