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AEZS-130 is a novel, oral growth hormone secretagogue (GHS) which exerts its effect by binding to the growth hormone secretagogue receptor GHS-R1A, which is the receptor for the physiological peptide ligand ghrelin.
Ghrelin is the natural ligand to a formerly "orphan" G-protein-coupled growth hormone secretagogue receptor (GHS-R),  specific to a family of growth hormone secretagogues (5,6).
Ghrelin is a small endogenous protein that acts on the Growth Hormone Secretagogue Receptor (GHSR), recognized as a key control point in the growth hormone signaling pathway, and a target for treatment of several metabolic disorders, including those related to body weight and body composition.