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Mediate the rejection reaction and achieve faster immune system recovery The immune cells present in the stem cell transplant can cause serious rejection reactions in the receiver; this is called the graft-versus-host reaction.
The microchimerism hypothesis is intriguing because many of the features of scleroderma are also features of graft-versus-host reaction, "and basically, that second event stimulates this graft-versus-host-like reaction to occur," he said.
The study suggests the researchers turned the graft-versus-host reaction to some patients' advantage, making it a graft-versus-tumor response.