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The scientists found that apigenin inhibited an enzyme called glycogen synthase kinase-3 beta (GSK-3 beta), which led to a decrease in the production of anti-apoptotic genes in the pancreatic cancer cells.
Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease.