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The research team is examining compounds which target the glycine receptor - one of the main receptors in the central nervous system - which is crucial in the sensation of chronic pain.
Probing the topology of the glycine receptor by chemical modification coupled to mass spectrometry.
Insulin-like growth factor-1 inhibits adult supraoptic neurons via complementary modulation of mechanoreceptors and glycine receptors.
Shea et al showed that intravenous propofol could compensate functionally for reduced glycine receptor response in a mouse model of hyperekplexia (9).
2006) because of low exposure levels; this dose-dependent effect is reminiscent of the biphasic effects of lead on glutamate neurotransmission shown to be dependent on glycine receptor affinity (Marchioro et al.
Therefore, anesthetics might work by blocking glutamate receptors or by activating GABA or glycine receptors.
The Company may develop inhibitors of these glycine transporters intended to increase the levels of glycine at the glycine receptor, which may be useful in treating symptoms of schizophrenia.
Most recently, a groundbreaking study traced the action of alcohols and volatile anesthetics on GABA and glycine receptors to two specific amino acid residues, paving the way for description of at least one receptor site (Mihic et al.