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Researchers evaluated the effects of a combination of vitamin C (1000 mg/day) and vitamin E (400 IU/day) on insulin sensitivity in about 40 healthy young men, as measured by glucose infusion rates (GIR) over a period of four weeks.
Subsequent glucose infusion rates were based on arterialized plasma glucose values obtained every 5 min.
Preliminary data are available for the primary endpoints of 1) total insulin exposure, calculated from the measured blood levels for insulin for eight hours post-injection (AUC(insulin0to8hrs)); 2) maximum concentration of insulin (Cmax(insulin)); 3) total glucose infused over eight hours (AUC(GIR0to8hrs)); and 4) maximum glucose infusion rate (GIR(max)).
Study data show that RHIIP had a faster onset of action than SC (time to reach 10 percent of total area under the glucose infusion rate (GIR) curve 73 vs 95 min.
Mikail and her associates measured traits associated with insulin resistance (as measured by glucose infusion rate, or GINF), including body mass index (BMI), lipid levels, blood pressure values, and fasting glucose levels.
In this study, administration of HE3286 to diabetic db/db mice markedly increased the glucose infusion rate (GIR) required to maintain normal levels of blood glucose following an intravenous infusion of a high dose of insulin.
A dose-response relationship was demonstrated by an increase in maximal glucose infusion rates (GIRmax: 0.
In this study, administration of HE3286 to diabetic db/db mice for 14 days markedly increased the glucose infusion rate (GIR) required to maintain normal levels of blood glucose following an intravenous infusion of a high dose of insulin.