What does GT stand for?

The contents reflect the diversification of mutagenesis approaches that now include, besides classical gene targeting, methods such as gene modification by oligonucleotides, gene trap mutagenesis, RNAi-mediated knockdown, and ENU mutagenesis.

Biological resources listed here include the Mutagenic Insertion and Chromosome Engineering Resource and the Sanger Institute Gene Trap Resource (both of which aid in developing genetically modified animal models), the WTSI Microarray Facility (which produces arrays for a range of organisms largely for use by Sanger researchers), and Clone Ordering (which allows external scientists to order mouse and human clone cells free of charge).

Separately, ACT announced that it has acquired the patents to a second generation cloning technology known as "cell fusion" and additional patents related to their gene trap technology.

Lexicon Genetics' (The Woodlands, TX) study identifying a novel gene target for the control of high blood pressure and detailing the creation of the largest gene trap library in the world has been published in the online Early Edition issue of the Proceedings of the National Academy of Science.

As a result, TIGM recently submitted 276,372 nucleotide sequence tags generated from its world's largest gene trap library of C57BL/6 mouse embryonic stem cells, to the Genome Survey Sequences division of the GenBank([R]) database.

In support of the IKMC's goals of free and open release of data, TIGM will begin to deposit our gene trap tag sequence data in the National Institutes of Health's GenBank library, beginning on or about June 1.

Lexicon's Human Gene Trap Database(TM) and OmniBank(R) library of gene-trapped mouse clones use custom bioinformatics software to compile and annotate both proprietary and publicly available genetic information and to create an integrated functional genomics platform for use by pharmaceutical and biotechnology companies in drug discovery.

Lexicon employs its proprietary Human Gene Trap database, OmniBank library of gene-trapped mouse clones and its web-based bioinformatics software in an integrated technology platform for drug discovery and drug target validation.