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Experience in human gene transfer trials showed that targeting hepatocytes with V vectors has the potential to correct diseases like hemophilia, congenital blindness, and lipoprotein lipase deficiency.
Ibaraki, Japan) has patented a method for highly efficient gene transfer into primate-derived embryonic stem (ES) cells has successfully been achieved by using a simian immunodeficiency virus vector (SIV) pseudotyped with VSV-G protein, which is a surface glycoprotein of vesicular stomatitis virus (VSV) The present invention provides simian immunodeficiency virus vectors for gene transfer to primate ES cells.
Second, although base substitutions, insertions and deletions, homologous recombination, and lateral gene transfer are discussed throughout the book, a generalized quantitative review of the relative contributions of these processes during the evolution of certain groups of microbial pathogens (e.
In spite of many preclinical studies demonstrating the efficacy of vascular gene transfer strategies to prevent neointimal formation following arterial injury, the long-term clinical success of such strategies is dependent on the demonstration of safe and effective delivery of vectors into diseased target vessels.
[Horizontal gene transfer is the transfer of genetic material between organisms and even species.
Anderson recalls, "because they demonstrated two vital components of gene therapy: first, that a functional human gene could be successfully inserted into the blood cells of a monkey, and second, that gene transfer using retroviruses was not harmful.
Immunology after in utero and neonatal gene transfer (Simon Waddington).
We have used polyethylenimine-mediated in vivo somatic gene transfer to introduce an estrogen response element-thymidine kinase-luciferase (ERE-TK-LUC) construct into the brain.