The higher throughput of the six-channel instrument will allow small biotech and pharmaceutical companies a cost-effective approach to medium-throughput, Aequorin-based G protein-coupled receptor (GPCR) and Luciferase-based Reporter Gene Screening," said Andy Boorn, president of MDS Analytical Technologies.
These gene families, which include G protein-coupled receptors, ion channels, kinases, nuclear receptors, phosphatases, phosphodiesterases, transporters, and proteases, contain the genes of greatest interest to the pharmaceutical industry as new drug targets.
Debiopharm Group (Debiopharm), a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs, and MSM Protein Technologies (MSM), a human antibody drug discovery company with world class expertise in targeting multi-spanning membrane proteins, announce the signature of an exclusive agreement for the development and commercialisation of Debio 0929, an antibody targeting a G protein-coupled receptor (GPCR), to be developed into a new oncology therapeutic drug.
00 Hardcover QP552 Growing evidence suggests that G protein-coupled receptors interact with scaffolding, cytoskeletal, and signaling proteins and that these interactions play a role in the targeting, anchoring, and functioning of the receptors in the plasma membrane, thus contributing to cell development and plasticity.
Membrane proteins, such as G protein-coupled receptors (GPCRs) and ion channels, comprise about a third of all existing drug targets, but are difficult to manipulate because they are normally embedded in the cell surface.
