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Samples in periodicals archive:
First-phase insulin response is another critical issue.
First-phase insulin response is a normal process of insulin-producing cells in the pancreas that is lost in patients who develop type 2 diabetes.
The drug was associated with a nearly fivefold increase in beta-cell function, he said, and it improved first-phase insulin response and insulin sensitivity in the study patients.
In addition, the exenatide data showed improvements in beta cell function, as measured by HOMA-B and proinsulin to insulin ratios, and the restoration of first-phase insulin response, a fundamental response lost early in the development of type 2 diabetes.
A first-phase insulin response is the normal pattern of insulin secretion found in healthy individuals, and it is lost early in the development of type 2 diabetes.
The study participants, who ranged in age from 4 to 45 years, were deemed to be at risk of developing the disease by virtue of immune markers and loss of first-phase insulin response.