What does FBI stand for?

PIK3CA, AKT1 mutation and HER2 amplification gene signatures (GS) suggest predominantly negative feedback inhibition of PI3K/AKT pathway in human breast cancer (BC).

The most viable of these include the Error Catastrophe Theory, related to faulty molecular transcription and errors in cellular function, the Crosslinkage Theory, in which progressively increasing cross-linking between proteins slows the body functions down, and the Neuroendocrine Theory, in which changes in homeostasis and hormone levels occur through time due to an increasing loss of sensitivity of receptors to feedback inhibition.

Androgenic phytonutrients from herbs (such as Tribulus terrestris, Muira puama, Avena sativa and nettle leaf), amino acids (including L-arginine) and certain foods such as melons naturally increase testosterone production without the danger of negative feedback inhibition as experienced with anabolic steroids and other hormones.