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Most of the insulin resistant patients were postmenopausal but, interestingly, most of them had fasting plasma glucose and/or fasting plasma levels in the normal range.
Fasting plasma glucose and other factors were measured upon enrollment and those with glucose levels of 110 mg/dL (classified as impaired fasting hyperglycemia by the World Health Organization) or higher were excluded.
Higher normal fasting plasma glucose is associated with hippocampal atrophy: the PATH Study.
Over the preceding nine years, their fasting plasma glucose levels and hemoglobin A1C (HbA1c, a measure of blood glucose control over time) had been tracked.
They used the EVA study data, which is a 9 year longitudinal study (1389 male and female subjects, aged 59-71 years), which measured fasting plasma glucose was at baseline, 2, 4 and 9 years.
When added to the common diabetes pill metformin, dapagliflozin cut both levels of both glycosylated hemoglobin--an indication of glucose concentration in the blood--and fasting plasma glucose in patients with type 2 diabetes after 24 weeks, hitting both its main and secondary targets.
We evaluated the association of serum selenium, measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry, and diabetes, defined as a self-report of current use of hypoglycemic agents or insulin or as fasting plasma glucose [greater than or equal to] 126 mg/dL.
has announced that MB07803 met its primary efficacy endpoint with results demonstrating a statistically and clinically significant reduction in fasting plasma glucose (FPG) at day 28 in its Phase 2a clinical trial.