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Extended criteria donors in liver transplantation: adapting donor quality and recipient.
The cost implications of using more extended criteria donors and donation after cardiovascular death should also be objectively explored.
A number of new authors were invited to update existing topics and take account of the problems of organ shortening with the use of extended criteria donors, new approaches and indications for liver transplantation for malignancies, a variety of infectious diseases, and other emerging matters.
The patients who received extended criteria donor (ECD) kidneys had a mean age of nearly 69 years, whereas their donors died at a mean age of almost 67 years.
Data presented included safety and efficacy results from three similarly designed clinical studies in adult de novo kidney transplant patients: a Phase 2 study (IM103100) and two Phase 3 studies, one in standard criteria (living or deceased) donor kidney transplants (IM103008) and one in extended criteria donor kidney transplants (IM103027).
Largest trial in extended criteria donors (BENEFIT-EXT) demonstrates benefits of belatacept across donor types [sup.
Data presented included safety and efficacy results from three similarly designed clinical studies in adult de novo kidney transplant patients; a Phase 2 study and two Phase 3 studies, one in standard criteria (living or deceased) donor kidney transplants and one in extended criteria donor kidney transplants.
73m2) and the high number of extended criteria donors are likely to account for the high incidence of graft dysfunction as a reason for efficacy failure.