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Findings from the WHI study in 2002 indicated a greater risk of breast cancer and heart disease among women who used a combination of estrogen and progestin as hormone replacement therapy in comparison with those who received a placebo.
Los Angeles Biomedical Research Institute (LA BioMed) lead researcher and colleagues, looked at postmenopausal women, who had no prior hysterectomy with negative mammograms within two years and were either users or non-users of estrogen and progestin combined therapy.
He notes that the combination therapy delivers estrogen and progestin in regular doses every day.
Overall, the difference between estrogen and progestin potencies had no impact on endometrial cancer incidence.
Based on the research to date, there is no apparent benefit to hormone therapy for cardiovascular disease, and there is even an increased risk for stroke with either estrogen alone or with estrogen and progestin.
Combined estrogen and progestin hormone therapy has reached new levels of controversy in recent months.
In contrast, women who had used only regimens containing both estrogen and progestin did not have a significantly elevated risk, although data were limited for this group.
Ortho Evra skin patch: Women place this dermal patch containing estrogen and progestin on the buttocks, abdomen, upper torso or outer-arm area once a week for three weeks.