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The study, supported by the British Heart Foundation, used mice to investigate the process by which these nitro fatty acids lower blood pressure, looking at whether they inhibited an enzyme known as soluble Epoxide Hydrolase which regulates blood pressure.
Among their topics are future perspectives for research on the biosynthesis of juvenile hormones and related sesquiterpenoids in arthropod endocrinology and ecotoxicology, roles of the juvenile hormone analog methoprene in gene transcription, population dynamics models for assessing the endocrine disruption potential of juvenile hormone analogues on non-target species, receptor-guided structure-activity modeling of inhibitors of juvenile hormone epoxide hydrolases, and using multicriteria analysis for selecting candidate insecticides for vector control.
1 Dipeptidase DPEP1 NM_214108 Epoxide hydrolase NM_214355 EPHX1 Liver expressed NM_213788 antimicrobial peptide 2 LEAP2 Arginine rich antibacterial NM_214355.
today announced the presentation of three posters that validate the mechanistic activity and therapeutic potential of the company's lead drug candidate, AR9281, an orally-administered soluble epoxide hydrolase (sEH) inhibitor that is in a Phase II clinical program for the treatment of type 2 diabetes.
Earlier research had suggested that a troublesome enzyme, called soluble epoxide hydrolase, degrades natural inflammation inhibitors known as epoxyeicosatrienoic acids (EETs).
Polymorphisms of N-acetyl-transferases, glutathione Stransferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
De Berardinis V, Moulis C, Maurice M, Beaune P, Pessayre D, Pompon D, Loeper J (2000) Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes.
It has been hypothesized that if the patient has a genetic or acquired defect in epoxide hydrolase activity, the metabolism of arene oxides will be impaired, and the resulting accumulation of the oxide can lead to hepatic injury.