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Examples of specific topics include the pharmacology of iron transport, the impact of soluble epoxide hydrolase and epoxyeicosanoids on human health, small molecule-based approaches to adult stem cell therapies, and unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences.
1 Dipeptidase DPEP1 NM_214108 Epoxide hydrolase NM_214355 EPHX1 Liver expressed NM_213788 antimicrobial peptide 2 LEAP2 Arginine rich antibacterial NM_214355.
glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protection against carcinogenesis, mutagenesis, and other forms of toxicity of electrophiles and reactive forms of oxygen.
Earlier research had suggested that a troublesome enzyme, called soluble epoxide hydrolase, degrades natural inflammation inhibitors known as epoxyeicosatrienoic acids (EETs).
Polymorphisms of N-acetyl-transferases, glutathione Stransferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Gastroenterol Clin Biol 16: 916-922 De Berardinis V, Moulis C, Maurice M, Beaune P, Pessayre D, Pompon D, Loeper J (2000) Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes.
It has been hypothesized that if the patient has a genetic or acquired defect in epoxide hydrolase activity, the metabolism of arene oxides will be impaired, and the resulting accumulation of the oxide can lead to hepatic injury.
National Food Research Institute (Tsukuba, Japan) has patented a method for isolating cDNA encoding a plant-derived epoxide hydrolase and an expression system of the enzyme in Escherichia coli are established, so as to permit the mass-scale production of the plant-derived epoxide hydrolase.