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We will use DNA origami/ephrin ligand nanoclusters to investigate whether the spatial organization and mechanical properties of ephrin ligand assemblies impact Eph receptor function and contribute to generating diversity in the pathway.
In addition, another gene of the ephrin family, EPHB2 has also been revealed to have a significant association with litter size in pigs (Fu et al.
Although the percentage of amino acid variation in the G protein is higher than that in all other NiV proteins (except the P protein), it is not surprising that the residues implicated in Ephrin B2 and B3 binding are conserved across the genotypes (27,28).
After this initial entry, ephrin A5 plays a role in further guidance.
The Eph-family ligands are called ephrins (for Eph receptor interacting proteins).
One of the largest families of guidance cues is the Eph receptors and their ephrin ligands.
Researchers report that a certain class of Eph receptors and ephrin ligands--proteins that cause cells to either repel or attract each other--control how nerve connections from the developing eye form maps that present what people see to visual centers in the brain.
The most significantly affected canonical pathways across the entire dataset, which contains the 1062 genes deregulated by Rhodiola, were the following: (a) communication between innate and adaptive immune cells, (b) eNOS signaling, (c) altered T and B cell signaling in rheumatoid arthritis, (d) axonal guidance signaling, (e) G-protein coupled receptor signaling, (f) glutamate receptor signaling, (g) ephrin receptor signaling, (h) cAMP-mediated, and (i) atherosclerosis signaling pathways.