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Samples in periodicals archive:
Low frequency 2Hz of electric stimulation may cause the brain to release endorphin and spinal cord to release a large number of enkephalin; 100Hz frequency may cause spinal cord to release a lot of dynorphin, while 15Hz frequency to release enkephalin and a small amount of dynorphin.
Our novel synthetic chemistry applied to naturally occurring enkephalin opioid peptides enable us to impart small-molecule, drug-like properties to peptides.
The researchers discovered that the gene encoding one of the key endogenous opioids, enkephalin, was expressed at a higher level in the offspring of mothers, who had consumed a junk food diet than in the offspring of mothers who ate standard rat feed.
A natural brain chemical called enkephalin surged as rats began to eat M&M chocolate sweets.
Thus the diencephalic endorphin and mesencephalic enkephalin neurons stimulate the serotonin neurons at the bulbus (28-30) The serotoninergic neurons at the dorsal horn of the spinal cord stimulate the intermediate neurons at the dorsal horn.
Here, it triggers cells to release the natural painkiller, enkephalin, to alleviate pain for four to six weeks.
Fink and his colleagues demonstrated that an HSV vector that produces the opioid peptide enkephalin reduces pain-related behavior in animal models of inflammatory pain, neuropathic pain, and pain caused by cancer (Pain Medicine 2009;10:1325-30).
In animal studies, the HSV vector containing the preproenkephalin gene produced enkephalin, which provided a continuous analgesic effect.