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The product has successfully completed Phase 2 studies for the treatment of ovarian and endometrial cancer and the Company is currently planning a Phase 3 trial in endometrial cancer under a Special Protocol Assessment.
From the ovarian and endometrial cancer genome data, the Johns Hopkins-led team identified 12 of the most frequently mutated genes in both cancers and developed the PapGene test with this insight in mind.
This set of three genes is mutated in 40% of the serous endometrial cancer tumors and in 15% to 26% of the other endometrial cancer subtypes.
Researchers report a good correlation between hysteroscopy and histopathology in the diagnosis of endometrial cancer among women with postmenopausal bleeding.
The committee opinion cited a number of reports comparing transvaginal ultrasonography with endometrial sampling that consistently found that an endometrial thickness of less than or equal to 4-5 mm in patients with postmenopausal bleeding reliably excluded endometrial cancer (ACOG Committee Opinion 440, August 2009).
Between 3 percent and 5 percent of women diagnosed with endometrial cancer are younger than 40 years, and more than 70 percent of these young women have never given birth.
Soy and Endometrial Cancer A meta-analysis of five case-control and two cohort studies examined the effects of soy intake on endometrial and ovarian cancer.
Introduction Endometrial cancer is the most common type of uterine cancer.