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Finally, although the results of the Encyclopedia of DNA Elements (ENCODE) project clearly illustrate that DNA sequences outside of genes are not "junk," determining the clinical significance of the mutations identified in these regions can be problematic.
The questions we can now ask are more sophisticated and will yield better answers than the ones we were asking nine years ago," says Eric Green, director of the National Human Genome Research Institute, which coordinated and funded the mammoth Encyclopedia of DNA Elements, or ENCODE, project.
The Encyclopedia of DNA Elements (ENCODE) (3) and modENCODE, (4-5) which are organized by National Human Genome Research Institute (NHGRI) to provide high-quality annotation of sequence-based functional elements in human, Caenorhabditis elegans and Drosophila melanogaster genomes, also have generated more than a terabyte of data.
Affymetrix is one of 16 multinational research centers receiving a total of $80 million to develop the expanded Encyclopedia of DNA elements, or ENCODE.
Last month the Encyclopedia of DNA Elements (ENCODE) Consortium, an international collaboration of research groups funded by the National Human Genome Research Institute, reported exciting data upending the view that large portions of the human genome contain "junk" DNA.
The Encyclopedia of DNA Elements (EN CODE) study was enormous: It is being published in some three dozen papers and review articles in four scientific journals, and 440 scientists from 32 labs around the world contributed to it.
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today announced grants totaling more than $80 million over the next four years to expand the ENCyclopedia Of DNA Elements (ENCODE) project, which in its pilot phase yielded provocative new insights into the organization and function of the human genome.
A milestone was reached in June, when a project called the Encyclopedia of DNA Elements (ENCODE) thoroughly mapped the functional regions in 1 percent of the human genome.