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In a paper published online in the journal Radiology, Dr Dow-Mu Koh, Professor Martin Leach and Professor Val Lewington claim that dynamic contrast enhanced (DCE-) MRI can be used to monitor and predict response to this therapy.
Presentation highlights include: -- A Phase I Study Evaluating the Safety, Pharmacokinetics, and Efficacy of ABT-263 in Subjects With Refractory or Relapsed Lymphoid Malignancies -- Reduction in Platelet Counts as a Mechanistic Biomarker and Guide for Adaptive Dose-escalation in Phase I Studies of the Bcl-2 Family Inhibitor ABT-263 -- Dynamic Contrast Enhanced MRI (DCE MRI) for Assessment of Effects of Anti-Angiogenic Therapy: Comparison of the Transfer Constant (Ktrans) to Blood Flow and Permeability Derived by a Distributed Parameter Model -- Relationship of Dose of ABT-869 on Biomarkers of Angiogenesis and Their Correlation With Pharmacodynamic (PD) Outcome Study Background and Results ABT-263
The Company also reported that certain patients with N-cadherin positive tumors displayed evidence of vascular effects in their tumors, such as changes in blood flow, as assessed by dynamic contrast enhanced MRI (DCE-MRI), and that the drug showed pharmacology properties that would support further clinical development.