What does DTI stand for?

Around one in 100 people given a direct thrombin inhibitor suffers bleeding severe enough to kill them -- unless they have urgent medical attention such as a transfusion.

Xarelto is one of the drugs, along with Bristol-Myers Squibb/Pfizer s investigational Factor Xa inhibitor and Boehringer Ingelheim s already-approved Pradaxa (dabigatran etexilate), an oral direct thrombin inhibitor, that is looking to challenge the market-leading position of Sanofi-Aventis Lovenox (enoxaparin) B-MS and Pfizer said last week that they will not be seeking approval for apixaban in 2009, as expected, after the drug failed in a late-stage trial for the prevention of VTE in patients undergoing total knee replacement.

Angiomax is a direct thrombin inhibitor designed to deactivate circulating and clot-bound thrombin and thrombin-mediated platelet activation.

1) Hirudin is a 65-amino-acid polypeptide first derived from the saliva of the medicinal leech, Hirudo medicinalis, and is the prototype direct thrombin inhibitor.

About ANGIOMAX ANGIOMAX is a small-molecule, reversible, direct thrombin inhibitor that has been shown to reduce the incidence of death, myocardial infarction, and the need for revascularization in patients undergoing balloon angioplasty.

The drug is a synthetic direct thrombin inhibitor that prevents clots from forming.

Demand for biotechnology cardiovascular and related agents will increase rapidly, led by new therapies for congestive heart failure, heparin-induced thrombocytopenia and thrombolytic surgical complications Direct thrombin inhibitors will exhibit the fastest growth based on expanding indications in surgery and emergency care.

The study evaluated the effects of lepirudin, a direct thrombin inhibitor, compared to standard heparin, an indirect thrombin inhibitor, in treating patients with unstable angina.