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The 2-5A antisense technology has shown promising in vitro datatargeting infectious diseases (herpes, human immunodeficiency virus), certain cancers (chronic myelogenous leukemia, glioblastoma), conditions modulated by 5-alpha reductase and dihydrotestosterone receptors (acne and androgenic, alopecia) and aspects of the interferon pathway that are mediated by PKR (a protein kinase enzyme).