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Samples in periodicals archive:
But the fact that up to 10 percent of adults are deficient in the vital DPD enzyme, called Dihydropyrimidine dehydrogenase, is bolstering Mr.
5FU is initially catabolized to 5-fluorodihydrouracil by dihydropyrimidine dehydrogenase (DPD) mainly in the liver.
Dihydropyrimidine dehydrogenase (DPD) is an enzyme that degrades 5-FU to an inactive metabolite.
Although the cytotoxic effects of 5FU are probably directly mediated via the anabolic pathways, the catabolic route plays an important role because >80% of the administered 5FU is catabolized by dihydropyrimidine dehydrogenase (DPD).
Eniluracil, an oral dihydropyrimidine dehydrogenase (DPD) inhibitor, was previously under development by GlaxoSmithKline for oncology indications.
Data have suggested that patients who are deficient in the enzyme dihydropyrimidine dehydrogenase (DPD) may be more vulnerable to adverse events with 5-FU, but severe toxicity is extremely rare (about one case in 2 million) with topical formulations.
But another common cause of overexposure is thought to be poor drug clearance: a genetic variation in certain patients results in deficient levels of an enzyme essential for 5-FU metabolism, dihydropyrimidine dehydrogenase (DPD).
Xeloda is contraindicated in patients who have a known hypersensitivity to 5-fluorouracil, and in patients with known dihydropyrimidine dehydrogenase (DPD) deficiency.