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Development of difluoromethylornithine (DFMO) as a chemoprevention agent.
In Detroit, Malia is receiving a new experimental treatment using difluoromethylornithine, or DFMO, which is already approved for use for African sleeping sickness and is being used in cancer trials, since it inhibits a key protein in tumor growth.
Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: effects of a difluoromethylornithine, a specific, irreversible inhibitor of' ornithine decarboxvlase.
professor of medicine and biological chemistry at the University of California, Irvine, presented late-breaking results from a phase III trial of difluoromethylornithine (DFMO), a synthetic inhibitor of ornithine decarboxylase, and sulindac (Clinoril), an NSAID, in 375 patients.
Difluoromethylornithine, an effective new treatment of Gambian trypanosomiasis.
Cells were grown to confluence at which point they were treated with difluoromethylornithine (DFMO), diethylglyoxal bisguanylhydrazone (DEGBG), or a combination of the two.
Agent PK PD (IEB) Antiestrogens Tamoxifen +3 +4 (ER) Raloxifene +4 +4 (ER) Flutamide +2 +4 (AR) NSAI Ds Sulindac +3 +4 (Cox-1/2) R-Flurbiprofen +3 +4 (Cox-1/2) Retinoids 4-HPR +4 +4 (IGF-1, apoptosis) 9-cis-RA +4 +4 (RAR/RXR) 13-cis-RA +4 +4 (RAR/all-trans-RA) Selenium Se-methionine +3 +4 (GSH peroxidase) Dehydroepiandrosterone +4 +4 (Androgenic, estrogenic) Difluoromethylornithine +1 +4 (Polyamines) Agent Issue Antiestrogens Tamoxifen Endometrial CA (+) Raloxifene Endometrial (CA (-) Flutamide Gynecomastia NSAI Ds Sulindac GI toxicity R-Flurbiprofen R > S (anti-CA) Retinoids 4-HPR Night blindness (retinol concns.
Difluoromethylornithine, a drug to stop the growth of metastases, severely reduces platelet counts in the blood of cancer patients.