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Since 1993, the Diabetes Autoimmunity Study in the Young (Denver, Colorado) has followed children who were at increased risk of type 1 diabetes (because of a particular HLA type or because a first-degree relative had type 1 diabetes).
From the German BABY-DIAB study (6) and the Diabetes Autoimmunity Study in the Young (DAISY) study, islet autoantibodies can first appear very early in life and are predictive of the later onset of T1DM.
The Diabetes Autoimmunity Study in the Young (DAISY), conducted in Denver, CO, between January 1994 and November 2006, examined 1770 children at increased risk for type 1 diabetes, defined as either possession of a high diabetes risk HLA genotype or having a sibling or parent with type 1 diabetes.