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These compounds are currently being developed to meet unmet clinical needs in conditions in which D2 and D3 dopamine receptors have been shown to play key roles.
The T4-L method has been validated and successfully applied to solve at least thirteen novel GPCR structures, including the beta 2 adrenergic receptor, the D3 dopamine receptor, the CXCR4 receptor, the H1 histamine receptor, the S1P1 receptor, the A2A adenosine receptor, the mu, delta, and kappa-opioid receptors, the M2 and M3 muscarinic receptors which have been reported in Science and Nature.
Requip is a second-generation dopamine agonist that has high in vitro specificity at the d2 and d3 dopamine receptor subtypes and works by mimicking the effects of dopamine.