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The most important effectors of the cell-mediated immune response, cytotoxic T lymphocytes, are the main immune cells that recognize foreign antigens on the surface of infected "self" cells.
These approaches include biologic therapy using interleukin (IL)-2, IL-12, interferon-alpha, monoclonal antibodies directed against B cell targets, cytotoxic T lymphocytes directed against viral targets, immune-based therapy, stem cell reconstitution, angiogenesis inhibitors, therapeutic vaccines, and traditional cytotoxic chemotherapy regimens (often in combination with a biologic or immunologic approach).
ALVAC-HIV induces the proliferation of cytotoxic T lymphocytes and contains genes coding for glycoprotein 120 and other HIV components in a canarypox vector.
Non-personalized HIV immunotherapies are unable to raise cytotoxic T lymphocytes against HIV antigens, fail to induce T cell memory, and, most importantly, do not provide antiviral protection against the patient's own particular virus," said Jean-Pierre Routy, M.
Heterosubtypic immunity to influenza A virus infection requires B cells but not CDS+ cytotoxic T lymphocytes.
Virologists have long known that cells called cytotoxic T lymphocytes (CTLs) battle viruses by latching onto an infected cell and delivering the kiss of death-an outburst of compounds that destroys both the cell and its infectious cargo.
CytoDyn's CRO, will present Phase I/II data demonstrating the antiviral effects and absence of liver toxicity in individuals who have failed Highly Active Antiretroviral Therapy (HAART) after Cytolin(R) was used to protect CD4+ T lymphocytes from the anti-self, anti-CD4 cytotoxic T lymphocytes that proliferate uniquely in humans infected with HIV.
Primary induction of human CD8+ cytotoxic T lymphocytes and interferon-gamma-producing T cells after smallpox vaccination.