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Real-time RT-PCR demonstrated that the expression of the cell cycle-driving molecule, cyclin-dependent kinase 4 (Cdk4), in HCC was significantly reduced by the treatments with vitamin K2, K3 and K5.
61554456 U40343; Cyclin-dependent kinase 4 U20498 inhibitor 2D (CDKN2D); p19- INK4D A4N 1.
Beach's team showed that the p16 protein inhibits the activity of two cell cycle proteins called cyclin-dependent kinase 4 (CDK4) and cyclin D1.