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However, this study indicates that nephrologists are divided regarding the ideal primary end point for a product in clinical development, such as risk of doubling serum creatinine, change in creatinine clearance rate, or GFR, leading to greater complexity for the manufacturers.
Reduced renal function can also be assessed with creatinine-based formulae such as the Cockcroft-Gault formula (5), which calculates creatinine clearance rate in mL/min, or the Modification of Diet in Renal Disease (MDRD)  formula, which calculates glomerular filtration rate in mL/min/1.
Patients had to have a creatinine clearance rate of at least 60 mL/min to be eligible for the study, and no recent change in the use of serum urate-lowering drugs.
2] or greater than 30, obstructive coronary artery disease, peripheral or cerebral vascular disease, renal insufficiency based on a creatinine clearance rate of less than 50 mL/min, or debilitation.
Prior to PCI, the average creatinine clearance rate was about 83 mL/min in all patients.
The study, done at Liverpool Hospital and Royal Melbourne Hospital, enrolled 23 adults with significant anemia--hemoglobin levels of less than 11 g/ dL--and severe kidney disease-a creatinine clearance rate of less than 30 mL/min.