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Adjust the dosing interval based on creatinine clearance
SAN FRANCISCO - Assessing renal health using a modified Cockroft- Gault equation to measure creatinine clearance was more sensitive than using the Modification of Diet in Renal Disease equation to estimate glomerular filtration rate when estimating risk for osteoporosis and fracture, a study of 400 postmenopausal Puerto Rican women showed.
Thus, pharmacokinetic modeling of an exogenous plasma creatinine clearance could be useful for assessing renal creatinine excretion in birds.
Similarly, a timed urinary creatinine clearance provides a simple, cheap and repeatable estimate of renal drug elimination (16), and affords an alternate means of identifying such patients.
Twenty-four hour urine collection was used for assessment of urinary protein excretion and creatinine clearance at 4 and at 8 weeks.
Reduced renal function can also be assessed with creatinine-based formulae such as the Cockcroft-Gault formula (5), which calculates creatinine clearance rate in mL/min, or the Modification of Diet in Renal Disease (MDRD)  formula, which calculates glomerular filtration rate in mL/min/1.
Adoption of the calculated glomerular filtration rate (also known as electronic glomerular filtration rate, or eGFR) as an adjunct to or replacement for the 24-hour urine creatinine clearance test has not been without its problems.
Renal function can be estimated using an estimated creatinine clearance or by glomerular filtration rate, in addition to the 24-hour urine.