What does CIMP stand for?

CpG Island Methylator Phenotype

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Samples in periodicals archive:

In the study, the researchers examined tumour tissue from 553 colorectal cancer patients, specifically looking for associations between self-reported hormone use and a specific DNA methylation pattern, called the CpG island methylator phenotype, or BRAF gene mutations.

Hormone therapy may protect women from colorectal cancer

1 CpG island methylator phenotype (CIMP) is a subset of colorectal carcinoma (CRC) characterized by concordant hypermethylation of multiple promoter CpG island loci2 and peculiar clinicopathologic findings, such as close association with microsatellite instability (MSI), proximal tumor location, female preponderance, high frequency of mutation of the protooncogene BRAF, and low frequency of mutation of the proto- oncogene KRAS.

CpG Island Methylator Phenotype in Colorectal Cancers: Comparison of ...

CpG Island Methylator Phenotype in Colorectal Cancer.

CpG Island Methylation in Cancer