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The results emphasize the importance of earlier detection and improved staging for contralateral breast cancer.
BRCA positive, mantle radiotherapy) remained constant, the general incidence of contralateral breast cancer had decreased.
SAN ANTONIO - BRCA mutation carriers can be separated into subgroups at low and sharply increased risks of developing contralateral breast cancer following a first breast cancer, a Dutch study suggests.
These elevated mutation frequencies and risks for contralateral breast cancer associated with these mutations underscore the need for women diagnosed with a first breast cancer at a young age -- regardless of family history -- to consider genetic testing and to discuss it with their health care providers," Malone said.
Women who carried certain rare ATM mutations-missense variants predicted to be deleterious-and who also received radiation had a higher risk of contralateral breast cancer compared with women who did not have these mutations and had not had radiation.
The researchers compared alcohol and smoking behaviors in 365 patients diagnosed with ER-positive breast cancer who developed a subsequent contralateral breast cancer with 726 controls diagnosed only with primary ER-positive breast cancer.
1) The study evaluated the prevalence of synchronous, occult, contralateral breast cancer detected by MRI but not by mammography or clinical breast examination.
First events were local recurrence (n=54), distant metastases (n=76), contralateral breast cancer (n=16), other second primary (n=17) and multiple disease events (n=7).