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After completing my doctoral thesis on this topic at the National University of Ireland, I started work with Sir Rory Collins and Sir Richard Peto in the Clinical Trial Service Unit (CTSU) at the University of Oxford in 1991.
SHARP was designed, conducted and analysed independently of all funding sources by the Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) of Oxford University, with guidance by an independent Steering Committee that included many of the world's leading kidney specialists.
A research team, led by Richard Peto and Gary Whitlock of the Clinical Trial Service Unit at the University of Oxford, pulled together data from 57 studies.
Dr Zhengming Chen, of Oxford's clinical trial service unit, said: "Giving this treatment could save 5,000 lives and prevent another 5,000 repeat heart attacks or strokes.
Dr Zhengming Chen, from Oxford's Clinical Trial Service Unit, who presented the results at the American College of Cardiology's annual meeting in Orlando, Florida, said: 'This means that, on average, adding clopidogrel to current therapies benefits one out of every 100 patients.
A team from the Clinical Trial Service Unit, Oxford, said the use of drugs called statins, which lower so-called "bad" cholesterol, had a significant effect in preventing ischaemic strokes - those caused by arterial blockages.
REVEAL is being led by Oxford University's Clinical Trial Service Unit, and is one of the largest cardiovascular studies ever conducted.
Rory Collins Professor of Medical Statistics and Epidemiology and Co-director of the Clinical Trial Service Unit, University of Oxford, Oxford, UK -and- Sir Richard Peto, F.