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001), clinical global impression of change-agitation (p=0.
The 11 subjects who completed the study showed significant improvements on the Brief Psychiatric Rating Scale, on the Clinical Global Impression, Bipolar version, and on measures of mood symptoms (see chart).
The primary outcome measures were the Clinical Global Impressions Improvement and Severity Scales (CGI-I and CGI-S); secondary outcomes were the Preschool Language Scale-4, Social Responsiveness Scale, Aberrant Behavior Checklist, and Vineland Adaptive Behavior Scales.
Intention-to-treat (ITT) analyses were performed on the primary outcome measure, the Hamilton rating scale for anxiety, the secondary variables, the clinical global impression of change (CGI-C), the Erlangen anxiety tension and aggression scale (EAAS), the list of complaints, and the patient's global rating of change.
In addition, tacrine-treated patients exhibited improvement in the Clinical Global Impression of Change, a subjective scale completed by both doctors and family members.
In addition to the favorable results on the Liebowitz scale over 12 weeks, participants showed statistically significant improvements on the Social Life/Leisure Activities domain of the Sheehan Disability Scale, the Clinical Global Impression Severity of Illness Scale, and the Clinical Global Impression Change Scale.
Efficacy outcome measures that were assessed at the beginning of the investigation and after 90 and 180 days of treatment included scores of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), the Mini-Mental State Examination (MMSE), the Global Deterioration Scale (GDS), the Alzheimer's Disease Assessment Scale-Behavioral Subscale (ADAS-Behav), all items of the Alzheimer's Disease Assessment Scale (ADAS-Total), and the Clinical Global Impression (CGI) scale.
The study investigators and patient clinical global impression on the treatment group were superior compared to placebo.