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B cells expand their receptor repertoire by rearrangements at the Igh locus; this process involves two prominent mechanisms: V(D)J recombination in developing B cells and class switch recombination in mature B cells.
The contributors review research findings on protein tyrosine phosphatases, interleukin-21, class switch recombination, thymus organogenesis, somatic hypermutation, and T follicular helper cells.
The research team led by Tasuku Honjo, a professor of molecular biology, found that a phenomenon called class switch recombination -- a genetic conversion allowing the production of antibodies by an immune cell -- can be induced in other types of cells if a special gene called AID is activated.