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Samples in periodicals archive:
These studies showed that N30 Pharma's GSNORi improved F508del-CFTR protein expression in transfected cells that overexpress F508del-CFTR as well as improving chloride channel activity in human airway cells derived from CF patients carrying two copies of the F508del-CFTR mutation.
Researchers from UCSF, Johns Hopkins University and Duke University have demonstrated that a specific calcium-activated chloride channel holds valuable clues to reducing two biological processes that contribute to the severity of asthma.
1551) investigated the effects of Cd on the expression of megalin and chloride channel 5 (C1C5), two key proteins involved in albumin-receptor-mediated endocytosis.
A] receptors to induce chloride channel opening, and modulate pentobarbital-induced pharmacological properties like a GABA receptors agonist.
Labeling for Amitiza, a chloride channel activator, states that efficacy was not demonstrated conclusively in men.
AMITIZA, which is discovered by Sucampo Pharmaceuticals, is the world's first selective chloride channel activator indicated for treating chronic idiopathic constipation.
It has been unclear how the gene associated with cystic fibrosis, CFTR, which acts as a chloride channel and a regulator of the sodium channel, causes lung disease," notes Marcus Mall, assistant professor in the School of Medicine.
The protein coded by the CFTR gene is a cAMP-regulated chloride channel in the apical membrane of epithelial cells.