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Radiation therapy with a single dose of eight hundred centigray administered to a limited field.
Karmanos researchers used a dose of two centigray units of absorbed radiation to mimic a CT scan and doses were administered at intervals of two, five and eight minutes.
The radiotherapy dose ranges from 2000-6150 centigrays (cGy) with a median dose of 4400 cGy.
Although these patients received doses of only one-third to one-half of the newly established dose of 15,000 centigray (cGy), all five patients demonstrated stabilization of their disease (one patient for thirty days, four patients for greater than sixty days).
In addition, they received 800 centigrays of total-body radiation followed by a final chemotherapy dose.
This therapy allowed the dosing of patients with up to 15,000 centigray of radiation energy, which is approximately a three-fold increase in the maximum safe dose that can be given by external beam radiation alone.
The objective of this study was to determine the efficacy of postoperative single dose radiation therapy of 700 centigray on fracture/dislocations of the elbow in the prevention of heterotopic ossification.
We are deliberately reducing the total-body irradiation from the typical pre-bone marrow transplantation regimen doses of 1,200 to 1,500 centigray which is equivalent to being close to the epicenter of a nuclear bomb blast, to 200 centrigray," says Dr.