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The carboxyl-terminal domain of the mammalian enzyme is related to bacterial restriction methyltransferases.
ApoE contains two important structural domains: an amino-terminal (residues 1-164) and a carboxyl-terminal domain (residues 201-299).
Additionally, pre-clinical data on RGB-286638 in solid tumor cell lines are being presented by GPC Biotech researchers in a poster entitled, "RGB-286638, a multi-targeted protein kinase inhibitor, induces apoptosis involving the inhibition of RNA polymerase II carboxyl-terminal domain phosphorylation and the loss of the anti-apoptotic BCL2 family member Mcl-1" (Abstract #3265).