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Author Affiliation(s):  Chairman, National Cancer Institute of Canada Clinical Trials Genitourinary Group (NCIC-CTG G-U) and Canadian Urologic Oncology Group (CUOG); Professor and Chief of Urology, Director of Urologic Oncology, Endowed Chair in Prostate Cancer, Centre Hospitalier de l'Universite de Montreal, Montreal, QC Correspondence: Dr.
10] Guidelines from the Canadian Urologic Oncology Group (CUOG) and the Canadian Urological Association (CUA) state that docetaxel plus prednisone is the standard of care for men with mCRPC, and the 3-weekly regimen is recommended for patients with clinical or biochemical evidence of disease progression and evidence of metastases.
7] The National Cancer Institute of Canada (NCIC) PR3/ Canadian Urologic Oncology Group (CUOG)/Medical Research Council (MRC) UK PR07 study randomized 1205 patients with high-risk, locally advanced disease to treatment with combined modality therapy (RT and lifelong ADT) or treatment with ADT alone.