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All of the patients provided a detailed personal history and were evaluated with the Brief Psychiatric Rating Scale (BPRS) and the Scale for the Assessment of Thought, Language, and Communication (TLC).
Safety assessments included adverse events, vital signs, electrocardiograms, clinical laboratory parameters, physician examination, Brief Psychiatric Rating Scale for Children (BPRS-C) and the Columbia-Suicide Severity Rating Scale (C-SSRS).
PTSD symptom severity (PTSD), the Brief Psychiatric Rating Scale (BPRS), General Assessment of Functioning (GAF), general life satisfaction, and activities of daily living (ADL) generally correlate .
 An exploratory subanalysis from a one-year, open-label trial of 80 elderly patients diagnosed with Alzhemier's disease who were treated with quetiapine compared with a subset of patients who were at least mildly hostile at baseline (n=46) showed significant improvement in total Brief Psychiatric Rating Scale (BPRS) scores and in three hostility measures (Factor V, BPRS Hostility Item, and Hostility Cluster Score).
The analysis evaluated change from baseline using the Brief Psychiatric Rating Scale (BPRS) for the 1,553 patients who remained on treatment for more than two weeks.
The impetus for the government-funded randomized trial was a small open-label Greek study; investigators concluded that 5 weeks of amisulpride at a mean dose of 101 mg/day brought significant improvements in the Brief Psychiatric Rating Scale and the Clinical Global Impression of Change Scale and was extremely well tolerated, with no safety issues (Int.
The primary endpoint is the proportion of patients with at least a 50 percent improvement in the Brief Psychiatric Rating Scale Positive Symptom Subscale (BPRS PSS) at both Day 7 and Day 28, a responder analysis.
A total of 100 patients were assessed 4 times over the 30 lunar cycles using the Brief Psychiatric Rating Scale (BPRS) and the Lancashire Quality of Life Profile.