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coli DH5[alpha] harboring pOrl-1-CTX-M-1 were tested for invasiveness in human brain microvascular endothelial cells (10) and in a newborn mouse (C57BL/6 wild-type) model of meningitis (R.
This tip seems to directly attach to the brain microvascular endothelial cells and then stimulate them to take in the pneumococcus.
HIV-1-infected mononuclear phagocytes downregulate tight junction protein and special polarized transport systems on brain microvascular endothelial cells (BMEC), as shown in human autopsy brain tissue and in severe combined immunodeficiency (SCID) mice with HIV (28).