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Vasodilatory response to bradykinin and calcium ionophore was significantly impaired in animals with HC+HT compared with each risk factor alone (P<0.
Agle and Ratnoff identified polypeptides similar to bradykinin occurring in subcutaneous tissues in these patients (7), (8).
3) Some studies have also shown that bradykinin accumulation and hypotensive episodes may be exacerbated in transfused patients taking angiotensin-converting enzyme (ACE) inhibitors (ACE-Is), because ACE is a key enzyme in the degradation of bradykinin.
Plasma kallikrein inhibitors are believed to reduce retinal vessel leakage by suppressing the chronic and excessive production of bradykinin.
The active substance, icatibant, is a specific bradykinin B2 receptor antagonist.
About FIRAZYR The active substance, icatibant, is a specific bradykinin B2 receptor antagonist.
Steroids and antihistamines are ineffective as the mechanism of the reaction is not allergic but related to bradykinin.
The researchers also found that bronchoconstriction was reduced by 34% when animals were treated with HOE-140, a bradykinin [[beta].