What does BSC stand for?

Poniard said more of the patients on best supportive care had received chemotherapy in the past, which might have affected the trial results.

published the predictive effect of the KRAS mutational status in patients included in a Phase III randomised controlled trial of panitumumab plus best supportive care (BSC) versus BSC alone in patients with chemorefractory mCRC [33].

5 mg/day, continuous daily dosing) plus best supportive care arm or the placebo plus best supportive care arm (n=79).

The rates of bleeding complications and infections were similar with best supportive care and risk of infection requiring intravenous antibiotic use was reduced by one-third with VIDAZA compared to conventional care regimens.

New England Journal of Medicine, 2007, 357, 2040-2048 This Phase III trial was conducted to compare single-agent cetuximab plus best supportive care in a total of 572 patients with epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer who had previously been treated with 5-fluorouracil or another thymidylate synthase inhibitor, and who had failed irinotecan and oxaliplatin.

Study Design APPRAISE is a double-blinded, randomized study of single agent seliciclib versus best supportive care in patients with NSCLC treated with at least two prior systemic therapies.

Panitumumab was tested for efficacy and safety in third-line metastatic CRC treatment and compared to best supportive care alone in patients who had failed prior standard chemotherapy.

Abstract #0236 In this study, data showed VIDAZA (azacitidine) provides a significant overall survival benefit for patients with higher-risk myelodysplastic syndromes (MDS) regardless of whether patients were treated with low-dose Ara-C or best supportive care in the control arm.