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The MRL derivation follows a NOAEL/LOAEL approach, or when data permit, derivation is based on benchmark dose modeling or physiologically based pharmacokinetic modeling (Chou et al.
the benchmark dose (BMD) and the no observed adverse effect level (NOAEL)].
10) Table 1 outlines toxicological reference values reported as Benchmark Dose Lower Limits (BMDLs) for various neurobehavioural endpoints reported from the above-mentioned epidemiological studies.
s] based on the NOAEL and benchmark dose (BMD) approaches.
These models were used to calculate benchmark dose values.
For example, they suggest that it will still be necessary to apply uncertainty or safety factors to no observed adverse effect levels or benchmark doses.
Such a calculation is sometimes referred to as a benchmark analysis, and the resulting POD as a benchmark dose (BMD) (Crump 1984).
To further elucidate the potential respiratory risks associated with airborne acrolein, we used benchmark dose modeling (BMD) to estimate the probability of respiratory effects at ambient concentrations of acrolein.