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Additionally, for women who have breast cancer and high cholesterol, taking statins may delay or prevent resistance to endocrine therapies such as tamoxifen or aromatase inhibitors.
Entinostat's proven ability to target multiple mechanisms of resistance establishes it as a promising candidate for preventing and overcoming aromatase inhibitor resistance through epigenetic modulation.
And if you switch to an aromatase inhibitor after taking tamoxifen for two to three years (for a total of five years), you get better results than if you take tamoxifen alone.
Aromatase inhibitors are a class of drugs used to treat breast cancer and ovarian cancer in post-menopausal women by blocking the synthesis of estrogen, which some cancers need in order to thrive.
SAN ANTONIO--Women who were premenopausal at diagnosis of early-stage breast cancer and subsequently completed 5 years of adjuvant tamoxifen derived additional benefit from extended aromatase inhibitor therapy, according to a new secondary analysis of a landmark clinical trial.
Arthralgias associated with aromatase inhibitor treatment have been increasingly recognised in the last few years.
The National Institute for Health and Clinical Excellence (Nice) will today back the use of aromatase inhibitors for women at any stage of breast cancer.
Aromatase inhibitors stop the natural production of oestrogen - the hormone that is responsible for the growth and recurrence of many breast cancers.