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18, 2014 /PRNewswire/ -- Polaris Group announced today that its lead product candidate ADI-PEG 20 (pegylated arginine deiminase) has received orphan drug designation for the treatment of malignant pleural mesothelioma (MPM) in the United States and in the European Union.
The amino acids lysine and arginine have been shown to respectively inhibit and stimulate herpes simplex virus (HSV) replication.
Arginine stimulates a hormone linked to the treatment of type 2 diabetes.
Willoughby DS, Boucher T, Reid J, Skelton G, Clark M (2011) Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise.
Recent data has demonstrated that it is upregulated especially in the ischaemic myocardium during ischaemia-reperfusion (17) and may in fact compete with endothelial nitric oxide synthase (eNOS) for arginine as a substrate, thus resulting in reduced NO production (18).
Arginine acts as a central node for regulating macrophage activation pathways (5).
The difference between the two versions of the gene amounts to one small change: swapping proline for arginine as the 72nd link in a chain of amino acids that make up a protein called p53.
During the second month, participants added 40 mg of Pycnogenol, taken twice per day, to their arginine supplementation.