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In contrast, other proapoptotic proteins such as nuclear factor-[kappa]B, cytochrome c, apoptosis-inducing factor, and cleaved poly(adenosine diphosphate-ribose) polymerase levels were significantly downregulated in the COC-treated group when compared with the untreated control group.
Specific topics include the age-dependence of neuronal apoptosis and of caspase activation, the significant role of apoptosis-inducing factor for brain damage following focal cerebral ischemia, the role of [micro]-calpain I and lysosomal cathepsins in hippocampal neuronal necrosis after transient global ischemia in primates, mitochondrial damage in traumatic central nervous system injury, hypoglycemic neuronal death, and the suspected role of a multi-functional protein--Tumor Suppressor p53--in seizure-induced neuronal cell death.
27) Flooding both the extracellular and intracellular pool with DHA may disrupt important homeostasis, which includes AA's ability to induce cell death through the release of apoptosis-inducing factor from the cancer cell mitochondria.
However, one protein, apoptosis-inducing factor (AIF), escaped from the mitochondrial membrane much more slowly and incompletely, starting with the release of cytochrome c but continuing over the next few hours, according to Douglas Green, Ph.
By blocking mitochondrial megapores, cyclosporin prevents the toxic release of cytochrome c and other apoptosis-inducing factors which forces the nerve cell down a cell death pathway.